How does FGF2 simultaneously promote beneficial remyelination and detrimental neuroinflammation in MS?

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Description

The abstract describes FGF2 as having dual roles - promoting myelination/remyelination while also contributing to neuroinflammation and disease exacerbation. The molecular mechanisms determining these opposing outcomes are not explained, limiting therapeutic targeting strategies.

Gap type: unexplained_observation Source paper: Molecular mechanism and the main signaling pathways in the development and progression of multiple sclerosis. (2025, Experimental cell research, PMID:40992569)

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