How does importin α1/β exert anti-aggregation activity beyond nuclear transport?

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Description

The abstract reveals that importin α1/β has anti-aggregation activity that is disrupted when TDP-43 binding is impaired, but the molecular mechanism of this protective function is not explained. Understanding this could reveal new therapeutic targets for preventing TDP-43 aggregation in sporadic ALS.

Gap type: unexplained_observation Source paper: Single Acetylation-mimetic Mutation in TDP-43 Nuclear Localization Signal Disrupts Importin α1/β Signaling. (None, None, PMID:39181183)

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