What are the specific biophysical mechanisms by which muscle-derived exerkines cross the blood-brain barrier and interact with synaptic machinery?

synaptic biology open
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Description

The abstract identifies exerkines as key mediators of exercise-induced neuroplasticity but explicitly notes fundamental gaps in understanding biophysical interactions between muscle activity and brain at cellular levels. This mechanistic gap limits development of targeted exercise interventions and potential therapeutic mimetics.

Gap type: open_question Source paper: Exerkines and long-term synaptic potentiation: Mechanisms of exercise-induced neuroplasticity. (2022, Frontiers in neuroendocrinology, PMID:35283168)

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