What are the specific molecular mechanisms by which LCA regulates M1/M2 microglial polarization?

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Description

The abstract shows LCA regulates M1/M2 markers and reduces gliosis, but the precise signaling pathways mediating this anti-inflammatory effect are not elucidated. Understanding these mechanisms is critical for optimizing LCA’s therapeutic potential and identifying downstream targets.

Gap type: unexplained_observation Source paper: Licochalcone A prevents cognitive decline in a lipopolysaccharide-induced neuroinflammation mice model. (None, None, PMID:39930360)

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