How does intrinsic thalamic P/Q channel function regulate embryonic neurogenesis and β-catenin signaling?

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Description

The finding that global but not cortical-specific P/Q deletion increases thalamic neurogenesis and β-catenin/Lef1 signaling reveals an unexpected developmental role. The mechanistic link between P/Q channel activity and Wnt/β-catenin pathway regulation in neurogenesis is completely unknown.

Gap type: unexplained_observation Source paper: Presynaptic P/Q calcium channel deficit promotes postsynaptic excitability remodeling and neurogenesis in developing thalamic circuitry. (2026, Neuron, PMID:41932329)

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