What determines the specificity of TFEB-induced signaling endosomes for different cargo types?

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Description

The abstract shows TFEB promotes endocytosis and formation of signaling endosomes carrying specific proteins like RRAGD and SLC38A9, but the mechanism controlling cargo selectivity is unexplained. This selectivity could be crucial for understanding protein aggregation clearance in neurodegeneration.

Gap type: unexplained_observation Source paper: TFEB-driven endocytosis coordinates MTORC1 signaling and autophagy. (None, None, PMID:30145926)

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