Why do MSC-EVs demonstrate superior regenerative effects compared to HEK293-EVs in neuroregeneration?

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Description

The abstract reports MSC-EVs outperformed HEK-EVs but doesn’t explain the mechanistic basis for this difference. Understanding this could inform optimal EV source selection and engineering strategies for neurotherapeutics.

Gap type: unexplained_observation Source paper: Engineered MSC-EVs loaded with BDNF-enhancing neuropeptides via a non-disruptive method enhance post-stroke neuroregeneration via intranasal delivery. (None, None, PMID:40883738)

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