Why does passive incubation preserve EV integrity better than active loading despite lower encapsulation efficiency?

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Description

The counterintuitive finding that gentler loading maintains function better than efficient active methods lacks mechanistic explanation. Understanding this trade-off is crucial for optimizing therapeutic EV engineering protocols.

Gap type: unexplained_observation Source paper: Engineered MSC-EVs loaded with BDNF-enhancing neuropeptides via a non-disruptive method enhance post-stroke neuroregeneration via intranasal delivery. (None, None, PMID:40883738)

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