Why do microbleeds occur predominantly in cortical layers 4-5 while CAA affects layers 1-2?

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Description

The study reveals a striking anatomical dissociation between microbleed locations (layers 4-5) and cerebral amyloid angiopathy (layers 1-2), discounting CAA as the cause of MBs. The underlying vascular or cellular differences driving this layer-specific vulnerability are unknown.

Gap type: unexplained_observation Source paper: Age, sex, and cerebral microbleeds in EFAD Alzheimer disease mice. (2021, Neurobiology of aging, PMID:33813349)

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