How do environmental factors and lifestyle specifically interact with epigenetic modifications to influence neurodegeneration?

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Description

The abstract identifies non-genetic factors including environmental elements and lifestyle as important in NDD etiology, but doesn’t explain how these factors mechanistically interact with epigenetic processes. Understanding these interactions is crucial for prevention strategies.

Gap type: unexplained_observation Source paper: Neuroepigenetics of ageing and neurodegeneration-associated dementia: An updated review. (2023, Ageing research reviews, PMID:37689143)

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