What are the specific mechanisms by which epigenetic alterations cause brain disorders in aging and neurodegeneration?

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Priority

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Description

The abstract explicitly states that alterations in the epigenome cause many brain disorders, but ‘the mechanisms behind it still need to be well understood.’ This mechanistic gap prevents targeted therapeutic development and limits understanding of disease causation.

Gap type: open_question Source paper: Neuroepigenetics of ageing and neurodegeneration-associated dementia: An updated review. (2023, Ageing research reviews, PMID:37689143)

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