What molecular mechanisms underlie the differential ADP-Ca2+ response in microglia versus macrophages?

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Description

The abstract shows iPSC-derived microglia respond to ADP with intracellular Ca2+ transients while macrophages lack this response, but the mechanistic basis is unexplained. Understanding this distinction could reveal fundamental differences in microglial versus peripheral immune cell signaling relevant to neuroinflammation.

Gap type: unexplained_observation Source paper: Directed Differentiation of Human Pluripotent Stem Cells to Microglia. (2017, Stem cell reports, PMID:28528700)

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