Why does C1q expression increase specifically in the corticothalamic system after mTBI?

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Description

The study demonstrates selective C1q upregulation in corticothalamic circuits, but the mechanisms underlying this anatomical specificity are not explained. This selectivity could reveal fundamental principles of how complement responds to brain injury and guide region-specific therapeutic approaches.

Gap type: unexplained_observation Source paper: Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury. (2021, Science (New York, N.Y.), PMID:34516796)

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