How do structural differences in STT3A versus STT3B catalytic subunits mechanistically drive OST complex assembly?

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Description

The abstract shows STT3A and STT3B structural differences facilitate contacts with distinct OST subunits (DC2 vs MAGT1), but the mechanistic basis for this selective assembly is not explained. Understanding this could reveal how OST dysfunction contributes to neurodegenerative protein misfolding.

Gap type: unexplained_observation Source paper: Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B. (2019, Science, PMID:31831667)

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