What molecular mechanisms determine the distinct substrate affinities of OST-A versus OST-B complexes?

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Description

The structures reveal OST-A binds only dolichylphosphate while OST-B binds both dolichylphosphate and acceptor peptide, suggesting different substrate affinities. The molecular basis for this selectivity remains unexplained, yet could be critical for understanding protein misfolding diseases.

Gap type: unexplained_observation Source paper: Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B. (2019, Science, PMID:31831667)

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