What are the specific mechanisms by which quercetin overcomes drug resistance in GBM treatment?

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Mechanistic

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Druggability

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Priority

80%

Importance

85%

Tractability

75%

Market price

50%

Description

The abstract notes that current GBM treatments fail due to drug resistance, and quercetin shows promise, but the mechanistic basis for how quercetin might circumvent resistance pathways is not explained. Understanding these mechanisms is critical for rational drug development and combination therapies.

Gap type: unexplained_observation Source paper: Quercetin induces MGMT (None, None, PMID:37451151)

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