What molecular mechanisms explain how β-catenin deletion preserves FCSC pools while blocking differentiation?

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Description

The study shows β-catenin deletion both inhibits Gli1+ cell differentiation into hypertrophic chondrocytes and preserves the stem cell pool during TMJOA. The mechanistic basis for this dual protective effect remains unexplained, limiting therapeutic targeting strategies.

Gap type: unexplained_observation Source paper: β-catenin Orchestrates Gli1+ Cell Fate in Condylar Development and TMJOA. (None, None, PMID:39400124)

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