How do β-catenin/Wnt and MAPK/ERK pathways interact with TrkB/BDNF signaling in honey-mediated antidepressant effects?

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Description

Authors explicitly identify the need to investigate additional signaling pathways beyond TrkB/BDNF. Understanding these pathway interactions is essential for comprehensive mechanism elucidation and identifying potential synergistic targets.

Gap type: open_question Source paper: Phytoconstituents of Indian mustard honey impart antidepressant activity in reserpine-induced depressed condition through activation of TrkB/CREB/BDNF pathway in hippocampus. (2026, Nutritional neuroscience, PMID:41017663)

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