How do agonistic IR antibodies achieve selective immune suppression without compromising protective immunity?

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Description

The abstract describes IR agonists suppressing pathological T cell functions while promoting tolerance, but the mechanisms ensuring selectivity are unexplained. This mechanistic gap is crucial for avoiding immunocompromise in treated patients.

Gap type: unexplained_observation Source paper: Inhibitory receptor agonists: Emerging strategies in immune modulation. (2026, J Exp Med, PMID:41915422)

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