What molecular mechanisms determine the asymmetric sensitivity of inhibitory vs excitatory synapses to microglial pruning?

synaptic biology open
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Description

The abstract shows that loss of inhibitory synapses has disproportionately greater impact on network dynamics than excitatory synapse loss, but the underlying molecular basis for this differential vulnerability is not explained. Understanding this selectivity could reveal targeted therapeutic approaches.

Gap type: unexplained_observation Source paper: Genome-wide consensus transcriptional signatures identify synaptic pruning linking Alzheimer’s disease and epilepsy. (None, None, PMID:41139712)

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