How do the identified platelet protein candidates (ATP6V0C, AP4B1, RAB2B, etc.) functionally relate to brain amyloid deposition?

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Description

While these proteins are identified as potential biomarkers for MCI with amyloid deposition, the functional connection between their platelet expression and brain amyloid pathology remains unexplained. This mechanistic gap limits understanding of whether these represent causal factors or mere correlates.

Gap type: unexplained_observation Source paper: Platelet proteomic signatures of amyloid β-positive mild cognitive impairment and Alzheimer’s disease. (2026, Molecular brain, PMID:41904574)

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