Why do GBA mutations cause earlier onset and distinct cognitive decline patterns specifically in Parkinson's disease?

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Description

The abstract notes that GBA mutations are associated with earlier PD onset and distinct cognitive decline, but doesn’t explain the mechanistic basis for these specific phenotypic modifications. This gap limits understanding of how lysosomal dysfunction shapes PD clinical presentation and progression.

Gap type: unexplained_observation Source paper: [GBA mutations and Parkinson’s disease]. (2018, Sheng li xue bao : [Acta physiologica Sinica], PMID:29926071)

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