How does CX43-mediated intercellular communication specifically activate STAT1 in this context?

neuro-oncology open
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Description

While CX43 inhibition alleviates chemoresistance, the mechanistic link between gap junction communication and STAT1 pathway activation remains unclear. This gap limits understanding of how astrocyte-tumor cell crosstalk drives therapeutic resistance in brain metastases.

Gap type: unexplained_observation Source paper: Astrocytes Protect Brain Metastatic Breast Cancer Cells From Chemotherapy Through CX43 Dependent STAT1 Signaling in Co-Culture Spheroids. (2026, Biotechnol Bioeng, PMID:41486609)

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