What are the shared pathophysiological mechanisms between normal cognitive aging and ADRD?

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Description

The abstract suggests shared mechanisms exist between age-related cognitive decline in healthy individuals and ADRD pathogenesis, but these common pathways remain undefined. Identifying these shared mechanisms could reveal early intervention targets before clinical dementia onset.

Gap type: unexplained_observation Source paper: Biological aging processes underlying cognitive decline and neurodegenerative disease. (2022, The Journal of clinical investigation, PMID:35575089)

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