How can translational animal models be developed to better align with human ADRD processes?

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Description

The authors explicitly state that new translational animal models that more closely align with human disease processes are necessary for therapeutic discovery. Current models appear inadequate for capturing the complexity of human ADRD pathogenesis, limiting translation of findings.

Gap type: open_question Source paper: Biological aging processes underlying cognitive decline and neurodegenerative disease. (2022, The Journal of clinical investigation, PMID:35575089)

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