How do the molecular profiles of iPSC-derived pericytes compare to native brain pericytes under hypoxic stress?

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Description

The authors acknowledge that molecular profiles of iPSC-PC under hypoxic conditions remain largely unexplored. This knowledge gap is essential for validating iPSC-PC as faithful models of endogenous pericytes and predicting their therapeutic efficacy in ischemic conditions.

Gap type: open_question Source paper: Brain pericytes derived from human pluripotent stem cells retain vascular and phagocytic functions under hypoxia. (2025, Stem cells (Dayton, Ohio), PMID:40737487)

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