What mechanisms underlie IL18's enhancement of CAR T cell cytolytic function against solid tumors?

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Description

The abstract shows that antigen-inducible IL18 improves CAR T cell cytotoxicity and in vivo efficacy, but the specific molecular pathways by which IL18 enhances effector functions are not explained. Understanding these mechanisms is critical for optimizing cytokine-engineered CAR T cells for neuroblastoma and other solid cancers.

Gap type: unexplained_observation Source paper: Preclinical Development of CAR T Cells with Antigen-Inducible IL18 Enforcement to Treat GD2-Positive Solid Cancers. (None, None, PMID:38593230)

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