How does antigen-inducible cytokine production compare to constitutive expression for CAR T cell persistence?

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Description

While the study demonstrates superior acute antitumor activity with inducible IL18, the long-term effects on CAR T cell persistence, exhaustion, and memory formation compared to constitutive cytokine expression remain unclear. This knowledge gap is crucial for designing durable CAR T cell therapies.

Gap type: open_question Source paper: Preclinical Development of CAR T Cells with Antigen-Inducible IL18 Enforcement to Treat GD2-Positive Solid Cancers. (None, None, PMID:38593230)

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