What are the downstream pathways by which SorLA regulates tau phosphorylation independently of amyloid processing?

neurodegeneration open
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Description

The dissociation of amyloid and tau pathologies by SorLA modulation suggests independent regulatory pathways, but the specific molecular mechanisms linking SorLA to tau post-translational modifications remain unknown. Understanding these pathways could reveal new therapeutic targets.

Gap type: unexplained_observation Source paper: SorLA deficiency dissects amyloid pathology from tau and cholinergic neurodegeneration in a mouse model of Alzheimer’s disease. (None, None, PMID:22986780)

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