How does HDAC4 regulate the observed protein changes in both normal aging and AD?

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Description

The pathway analysis identified HDAC4 as a key regulator of protein changes in both genotypes, but the specific mechanisms by which HDAC4 controls these proteome alterations are not elucidated. Understanding this regulatory network could reveal therapeutic targets for memory preservation.

Gap type: unexplained_observation Source paper: Hippocampal proteomics defines pathways associated with memory decline and resilience in normal aging and Alzheimer’s disease mouse models. (None, None, PMID:27265785)

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