What principles guide optimal combination of autophagy modulators with epigenetic drugs in neurodegeneration?

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Description

The abstract mentions combining autophagy activators/inhibitors with epigenetic drugs but provides no mechanistic framework for rational combination design. This knowledge gap limits translation of autophagy-epigenetic crosstalk into effective therapies.

Gap type: open_question Source paper: Epigenetic and post-translational modifications in autophagy: biological functions and therapeutic targets. (2023, Signal transduction and targeted therapy, PMID:36646695)

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