How do genetic mutations in Shank3, Syngap1, Fmr1, and Nlgn3 specifically disrupt hippocampal synaptic plasticity in ASD?

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Description

The abstract identifies key genetic mutations that disrupt synaptic plasticity and social memory circuits, but the specific molecular mechanisms linking these mutations to hippocampal dysfunction remain unclear. Understanding these pathways is critical for developing targeted therapeutic interventions.

Gap type: unexplained_observation Source paper: Review on the role of hippocampus in autism spectrum disorder: Recent insights into neuropathology, genetics, and emerging therapeutic strategies. (2026, Neurobiology of disease, PMID:41412318)

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