What molecular mechanisms drive pT217-tau trafficking between excitatory neurons at synapses?

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Description

The study observes interneuronal trafficking of pT217-tau at synapses but doesn’t explain the underlying transport mechanisms. Understanding this process is critical since it may represent a pathway for tau pathology spread in Alzheimer’s disease.

Gap type: unexplained_observation Source paper: Nanoscale imaging of pT217-tau in aged rhesus macaque entorhinal and dorsolateral prefrontal cortex: Evidence of interneuronal trafficking and early-stage neurodegeneration. (2024, Alzheimer’s & dementia : the journal of the Alzheimer’s Association, PMID:38445818)

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