What triggers irreversible SERCA2 Cys oxidation in the context of vascular calcification?

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Description

The abstract mentions irreversible oxidation of SERCA2 cysteine residues but the abstract appears incomplete, cutting off mid-sentence. The upstream oxidative triggers and their relationship to neurodegeneration-associated vascular pathology remain unclear.

Gap type: unexplained_observation Source paper: SERCA2 Dysfunction Drives Vascular Calcification via Coupling with TSPO-MCU at Mitochondria-Associated Endoplasmic Reticulum Membranes. (2026, Pharmacol Res, PMID:41932666)

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