How does empagliflozin specifically inhibit β-catenin ubiquitination in cerebral endothelial cells?

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Description

The study shows empagliflozin prevents β-catenin ubiquitination and promotes nuclear translocation, but the molecular mechanism by which this SGLT2 inhibitor interferes with the ubiquitin-proteasome pathway is not explained. Understanding this mechanism is crucial for developing targeted neuroprotective strategies.

Gap type: unexplained_observation Source paper: Pre-ischaemic empagliflozin treatment attenuates blood-brain barrier disruption via β-catenin mediated protection of cerebral endothelial cells. (2025, Cardiovascular research, PMID:40173314)

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