Why does RAB21 depletion selectively affect SLC2A1 recycling but not IGF2R or WLS retrograde transport?

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Description

The selective effect on SLC2A1 versus other retromer cargoes suggests cargo-specific regulation mechanisms that are not explained. This selectivity could reveal novel therapeutic targets for metabolic diseases and cancer where glucose transport is dysregulated.

Gap type: unexplained_observation Source paper: RAB21 controls autophagy and cellular energy homeostasis by regulating retromer-mediated recycling of SLC2A1/GLUT1. (None, None, PMID:35993307)

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