What is the molecular mechanism by which RAB21 regulates fission of retromer-decorated endosomal tubules?

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Description

The authors speculate that RAB21 regulates tubule fission based on accumulation of SNX27-retromer on enlarged endosomes, but the actual molecular mechanism is unknown. Understanding this mechanism is crucial for comprehending how endosomal dynamics control cellular energy homeostasis and autophagy.

Gap type: unexplained_observation Source paper: RAB21 controls autophagy and cellular energy homeostasis by regulating retromer-mediated recycling of SLC2A1/GLUT1. (None, None, PMID:35993307)

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