How does DMF improve sickle cell pathology without reducing hemolysis or plasma heme levels?

oxidative stress biology open
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Description

The study shows DMF provides therapeutic benefits including reduced hepatic necrosis and inflammation, yet plasma hemoglobin and heme levels remained unchanged, indicating hemolysis was not decreased. This contradicts the expected mechanism where reducing oxidative stress should decrease hemolysis-driven pathology.

Gap type: contradiction Source paper: Control of Oxidative Stress and Inflammation in Sickle Cell Disease with the Nrf2 Activator Dimethyl Fumarate. (2017, Antioxidants & redox signaling, PMID:26914345)

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