What mechanisms explain DMF's increase in hemoglobin F production in sickle cell disease?

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Description

The abstract reports that chronic DMF treatment increased hemoglobin F levels, but provides no mechanistic explanation for how Nrf2 activation leads to fetal hemoglobin induction. This represents an unexpected therapeutic effect that could have major clinical implications for sickle cell treatment.

Gap type: unexplained_observation Source paper: Control of Oxidative Stress and Inflammation in Sickle Cell Disease with the Nrf2 Activator Dimethyl Fumarate. (2017, Antioxidants & redox signaling, PMID:26914345)

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