What is the optimal therapeutic time window to preserve beneficial neuroinflammatory processes while mitigating harmful chronic gliosis?

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Description

The authors explicitly identify difficulty in determining when to intervene, as neuroinflammation has both protective and detrimental roles. This timing question is critical for clinical translation of anti-neuroinflammatory therapies in AD.

Gap type: open_question Source paper: Role of chronic neuroinflammation in neuroplasticity and cognitive function: A hypothesis. (2022, Alzheimer’s & dementia : the journal of the Alzheimer’s Association, PMID:35234334)

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