How do TNF-α-lowering compounds achieve sufficient brain penetration for therapeutic efficacy in neurodegeneration?

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Description

The abstract identifies poor brain penetration as a key limitation for TNF-α targeting drugs. This pharmacokinetic barrier prevents translation of promising neuroinflammation targets into effective therapies.

Gap type: open_question Source paper: Role of chronic neuroinflammation in neuroplasticity and cognitive function: A hypothesis. (2022, Alzheimer’s & dementia : the journal of the Alzheimer’s Association, PMID:35234334)

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