Why does GPR109A blockade only partially abolish niacin's neuroprotective effects in colitis-induced depression?

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Description

The study shows mepenzolate bromide (GPR109A blocker) only partially reverses niacin’s beneficial effects on depressive behavior and neuroinflammation. This suggests additional GPR109A-independent pathways contribute to niacin’s neuroprotection, but these mechanisms remain unidentified.

Gap type: unexplained_observation Source paper: Niacin modulates depressive-like behavior in experimental colitis through GPR109A-dependent mechanisms. (None, None, PMID:37544378)

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