What is the therapeutic window and dosing strategy for urolithin A in preventing diabetes-induced amyloidogenesis?

neurodegeneration open
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Description

While urolithin A shows neuroprotective effects against high glucose-induced amyloidogenesis, the optimal timing, duration, and dosing for therapeutic intervention remain undefined. This knowledge gap limits clinical translation of this gut microbiome-derived metabolite.

Gap type: open_question Source paper: Urolithin A suppresses high glucose-induced neuronal amyloidogenesis by modulating TGM2-dependent ER-mitochondria contacts and calcium homeostasis. (2021, Cell Death Differ, PMID:32704090)

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