How can therapeutic strategies be adapted to overcome age-related differences in immune responses and neurovascular integrity post-stroke?

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Description

The authors explicitly identify a substantial translational gap in adapting emerging therapies to the aged brain, citing differences in immune responses and neurovascular integrity. This represents a critical barrier to developing effective stroke treatments for the most vulnerable population.

Gap type: open_question Source paper: The age-associated decline in neuroplasticity and its implications for post-stroke recovery in animal models of cerebral ischemia: The therapeutic role of extracellular vesicles. (2026, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, PMID:40770923)

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