How do the 52 PFAS-associated genes mechanistically connect prenatal exposure to impaired childhood immune responses?

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Description

While the study identifies 52 genes associated with both PFAS exposure and immune outcomes, the functional relationships and causal pathways linking these genes to immune dysfunction remain unclear. This mechanistic gap limits understanding of how early environmental exposures program long-term immune and potentially neurodevelopmental outcomes.

Gap type: unexplained_observation Source paper: Cord blood gene expression supports that prenatal exposure to perfluoroalkyl substances causes depressed immune functionality in early childhood. (2016, Journal of immunotoxicology, PMID:25812627)

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