How does the Vcp-Washc4 interaction specifically regulate autophagy versus other Vcp functions?

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Description

Both proteins affect autophagy, but Washc4 shows selective autophagy impairment without proteasome dysfunction, unlike Vcp. The molecular basis for this functional specificity within the Vcp interactome remains unclear, limiting understanding of targeted therapeutic approaches.

Gap type: unexplained_observation Source paper: Loss of the novel Vcp (valosin containing protein) interactor Washc4 interferes with autophagy-mediated proteostasis in striated muscle and leads to myopathy in vivo. (2018, Autophagy, PMID:30010465)

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