How does lysosomal stress activation contribute to GBM cell death following SMPD1 inhibition?

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Description

The abstract mentions lysosomal stress as a mechanism of GBM killing but doesn’t explain how SMPD1 inhibition triggers this pathway. Understanding this connection could reveal additional therapeutic targets and explain the selectivity for cancer versus normal brain cells.

Gap type: unexplained_observation Source paper: Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug. (None, None, PMID:34731610)

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