Why does endothelial YAP/TAZ loss reduce stroke lesions when YAP/TAZ typically promote tissue repair?

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Description

The finding that YAP/TAZ depletion is neuroprotective contradicts established roles of these proteins in promoting regeneration and tissue repair. This unexpected result challenges current understanding of YAP/TAZ function in vascular injury responses.

Gap type: contradiction Source paper: Loss of Endothelial YAP/TAZ Reduces the Size of Chronic Stroke Lesions and Alters the Endothelial Environment. (2026, Journal of the American Heart Association, PMID:41294142)

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