What molecular mechanisms underlie the reversed STDP polarity in corticostriatal synapses?

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Description

The abstract reports that corticostriatal STDP is reversed compared to other brain regions, with pre-before-post timing inducing LTP instead of LTD. The cellular and molecular basis for this unique temporal learning rule is not explained, yet it may be critical for understanding striatal dysfunction in movement disorders.

Gap type: unexplained_observation Source paper: Bidirectional activity-dependent plasticity at corticostriatal synapses. (2005, The Journal of neuroscience : the official journal of the Society for Neuroscience, PMID:16339023)

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