Why does NfL correlate with cognitive but not motor decline in Parkinson's disease?

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Description

The abstract implies NfL specifically predicts cognitive impairment rather than motor progression in PD, suggesting differential vulnerability of neural circuits. This selectivity pattern could reveal distinct pathophysiological mechanisms underlying cognitive versus motor symptoms.

Gap type: unexplained_observation Source paper: Neurofilament Light Chain as a Biomarker for Cognitive Decline in Parkinson Disease. (2021, Movement disorders : official journal of the Movement Disorder Society, PMID:34480363)

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